Class & Mechanism
Selank, previously known as TP-7, is a synthetic peptide derived from a combination of the sequence of tuftsin and another sequence to enhance its stability. Tuftsin is a naturally occurring part of the immunoglobulin G (IgG) antibody. Selank acts as an anxiolytic, antidepressant, and nootropic peptide, modulating immune response, enhancing memory, and improving cognitive function by elevating brain-derived neurotrophic factor (BDNF) in the hippocampus and influencing monoamine neurotransmitters [1][2].
Research-documented benefits
– Enhances memory and cognitive function [1].
– Exhibits antianxiety, antidepressant, and antiasthenic properties [1].
– Modulates Interleukin-6 and balances T cell cytokines [1].
– Reduces the breakdown of enkephalins [1].
General-knowledge benefits
– Selank is known to have anxiolytic effects, which are supported by its ability to reduce anxiety-like behavior in various animal models.
– The peptide has shown potential in improving learning and memory, which is beneficial in conditions such as Alzheimer's dementia and mild cognitive impairment (MCI).
– It may also decrease beta-amyloid deposition and tau protein phosphorylation, which are hallmarks of neurodegenerative diseases like Alzheimer's.
Typical injectable protocol
Adult human dose: 215 mg (1cc) IM/Sub Q daily, 7 days a week, for a 4-week cycle. Selank can also be administered as a 215 mg/ml solution for IV drip, 2 times a week for 2 weeks [1].
Key risks / contraindications
– More than the maximum dosages can lead to desensitization [1].
– Selank should be used cautiously in individuals with a history of psychiatric disorders or those taking medications that affect neurotransmitter levels.
Bottom line
Selank is a potent anxiolytic and cognitive-enhancing peptide used to treat anxiety disorders, improve memory, and support cognitive function in conditions like Alzheimer's and MCI.
References
- Basic and Clinical Aspects of Growth Hormone
- Boundless Upgrade Your Brain, Optimize Your Body and Defy — Ben Greenfield
- Growth Hormone Secretagogues
- Growth Hormone Secretagogues in Clinical Practice
- Handbook of Biologically Active Peptides
- Handbook of Neurochemistry and Molecular Neurobiology_ Neurotransmitter Systems
- Kosmetik für Ärzte und Apotheker
- Life Force
- Molecular Neuroscience
- Neuroprotective Effects of Tripeptides—Epigenetic Regulators — Khavinson, Vladimir (author)
- Peptide Protocols Volume One — William A Seeds MD
- Peptide drug discovery and development _ Translational — edited by Miguel Castanho and
- Peptides_ Chemistry and Biology, 2nd Edition
- Pharmacological Sciences_ Perspectives for Research and Therapy in the Late 1990s
- The Perricone Prescription
- The glucagon-like peptides