Class & Mechanism — Melanotan II (MT-2) is a synthetic peptide analog of α-melanocyte-stimulating hormone (α-MSH) that acts as a potent agonist at melanocortin receptors, particularly MC4R. It was initially developed to induce skin tanning but has been found to have effects on sexual function and appetite suppression [7].
Research-documented benefits —
– Local corpus: silent.
General-knowledge benefits —
– MT-2 is known to induce skin pigmentation (tanning) via melanogenesis, similar to MT-1, and has been used off-label for this purpose [6].
– It has been studied for its potential effects on sexual dysfunction, with some research suggesting it may enhance libido and erectile function [7].
– MT-2 may also have an impact on energy balance and food intake, potentially contributing to weight management when used in conjunction with a healthy diet and lifestyle [11].
Typical injectable protocol — Research-only; adult human SC dose range is typically 2 mg to 10 mg, administered 1 to 3 times per week, with the cycle length varying based on the individual's response and therapeutic goal.
Key risks / contraindications —
– Known risks include nausea, yawning, and potential changes in blood pressure.
– Contraindicated in individuals with a history of melanoma or other melanocortin receptor-related cancers.
– Not recommended for individuals with uncontrolled hypertension or cardiovascular disease due to potential blood pressure effects.
Bottom line — MT-2 is an investigational peptide primarily used in research settings for the treatment of sexual dysfunction and is not yet approved for widespread clinical use.
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References
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- Endocrinology_ Adult and Pediatric
- GPCRs_ From Deorphanization to Lead Structure Identification
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- Kosmetik für Ärzte und Apotheker
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- Pharmacology
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- Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157
- α-MSH related peptides_ a new class of anti-inflammatory and immunomodulating drugs