Class & Mechanism — IGF-DES, or Des(1-3)-IGF-1, is a variant of insulin-like growth factor 1 (IGF-1) that has been modified by deleting the first three amino acids, resulting in increased resistance to proteases and a longer half-life compared to native IGF-1. It acts by binding to the type 1 IGF receptor, leading to the activation of intracellular signaling pathways that promote cell growth and differentiation [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50].
Research-documented benefits — Local corpus: silent.
General-knowledge benefits — IGF-DES is believed to have similar effects to native IGF-1 but with a longer duration of action due to its resistance to degradation. It is being studied for its potential to promote muscle growth, enhance recovery from injuries, and improve overall tissue repair.
Typical injectable protocol — Research-only; typical experimental doses are not well-established but are presumed to be in the range of 50-150 μg/kg, administered subcutaneously or intramuscularly, with frequency varying depending on the study design.
Key risks / contraindications — Potential risks include the promotion of abnormal cell growth and hypoglycemia. Contraindicated in individuals with diabetes, cardiovascular disease, or a history of cancer.
Bottom line — IGF-DES is an experimental peptide used in research to study its effects on growth, recovery, and tissue repair, with potential applications in muscle wasting disorders and injury recovery.
References
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- Endocrinology_ Adult and Pediatric
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- Goodman and Gilman's The Pharmacological Basis of Therapeutics
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- Growth hormone-releasing peptide (GHRP)
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- Muscle_ Fundamental Biology and Mechanisms of Disease
- Peptides and Non Peptides of Oncologic and Endocrine Interest