Class & Mechanism — IGF-1 LR3, also known as Long R3 Insulin-like Growth Factor 1, is a long-acting analog of the naturally occurring IGF-1. It has been genetically modified to resist proteolytic degradation, extending its half-life and enhancing its biological activity. The primary mechanism involves binding to the type 1 IGF receptor, leading to activation of the PI3K/Akt signaling pathway, which promotes cell growth, differentiation, and survival [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50].
Research-documented benefits — Local corpus: silent.
General-knowledge benefits — IGF-1 LR3 is known to stimulate muscle growth, enhance recovery from injury, and potentially increase bone density. It is often used in research studying the effects of IGF-1 on growth, development, and muscle wasting conditions.
Typical injectable protocol — Research-only; typical experimental doses range from 50 to 150 μg/kg, administered subcutaneously or intramuscularly, with frequency varying depending on the study design.
Key risks / contraindications — Potential risks include hypoglycemia, fluid retention, and the promotion of abnormal cell growth. Contraindicated in individuals with diabetes, cardiovascular disease, or a history of cancer.
Bottom line — IGF-1 LR3 is an experimental growth factor used in research to understand its impact on muscle growth, recovery, and the potential treatment of muscle wasting disorders.
References
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- Growth Hormone Secretagogues in Clinical Practice
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- Muscle_ Fundamental Biology and Mechanisms of Disease
- Peptides and Non Peptides of Oncologic and Endocrine Interest