Class & Mechanism
Sermorelin is a synthetic analog of endogenous Growth Hormone-Releasing Hormone (GHRH), consisting of the first 29 amino acids of the 44-amino acid polypeptide hormone. It stimulates the synthesis and release of growth hormone (GH) from the anterior pituitary gland, thereby increasing circulating GH levels and subsequently insulin-like growth factor 1 (IGF-1) [29].
Research-documented benefits
– Significantly promotes the release of growth hormone (GH), improving serum concentrations of GH and IGF-1 [1].
– Best time to inject is right before sleeping to increase the amplitude of the largest natural GH pulse, which occurs during the first REM cycle [1].
General-knowledge benefits
– Used in clinical medicine to diagnose pituitary deficiency by measuring the serum GH response following a single IV infusion [29].
– Commonly used in the treatment of growth hormone deficiency in children, providing benefits such as enhanced IGF-1 output and increased linear height [29].
Typical injectable protocol
Adult human doses typically range from 0.1 mg to 0.2 mg, administered subcutaneously 2-3 times daily [29].
Key risks / contraindications
– As a potentiator of GH release, it may exacerbate conditions affected by GH excess, such as acromegaly or certain tumors [3].
– Long-term safety data is limited, and it should be used with caution in individuals with a history of cancer or other proliferative disorders.
– Not recommended for use in individuals with a known pituitary disorder.
Bottom line
Sermorelin acetate is a therapeutic peptide used to stimulate the release of growth hormone, primarily for the diagnosis and treatment of growth hormone deficiency. Its use should be approached with caution due to potential risks associated with increased GH levels.
References
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