Class & Mechanism — HMG, or human menopausal gonadotropin, is a mixture of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) derived from the urine of postmenopausal women. It acts on the FSH and LH receptors, stimulating the development of ovarian follicles and the production of estrogen and progesterone. HMG is used clinically to induce ovulation in fertility treatments [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50].
Research-documented benefits — Local corpus: silent.
General-knowledge benefits — HMG is known to stimulate ovarian follicle development and estrogen production, making it a key component in controlled ovarian hyperstimulation protocols for in vitro fertilization (IVF).
Typical injectable protocol — Clinical use: 75-300 IU of FSH and 75-300 IU of LH activity administered intramuscularly or subcutaneously, typically in a daily cycle for 5-12 days, depending on the response.
Key risks / contraindications — Potential risks include ovarian hyperstimulation syndrome (OHSS), multiple pregnancies, and cardiovascular risks. Contraindicated in individuals with uncontrolled thyroid or adrenal disorders, or a history of ovarian hyperstimulation.
Bottom line — HMG is a clinically approved fertility treatment used to induce ovulation and is a key component in controlled ovarian hyperstimulation protocols for IVF.
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