Class & Mechanism
SS-31, also known as Elamipretide or Bendavia, is a mitochondria-targeted peptide that contains the antioxidant 2′,6′-dimethyltyrosine residue. It is designed to accumulate within the mitochondria, where it can scavenge reactive oxygen species (ROS) and protect the mitochondria from oxidative damage. The primary biological effect of SS-31 is the preservation of mitochondrial function and the attenuation of oxidative stress, which is implicated in various diseases and aging processes [8].
Research-documented benefits
Local corpus: silent.
General-knowledge benefits
SS-31 has been studied for its potential therapeutic effects in conditions associated with mitochondrial dysfunction and oxidative stress. It has shown promise in preclinical models of diseases such as Barth syndrome, Leber's hereditary optic neuropathy, and Duchenne muscular dystrophy [9]. Additionally, SS-31 has been investigated for its potential to ameliorate inflammation, oxidative stress, and leukocyte-endothelium interactions in type 2 diabetes [9].
Typical injectable protocol
The typical injectable protocol for SS-31 is not well-established in the literature. However, based on its use in clinical trials, it is generally administered intravenously (IV) in the range of milligrams (mg) per dose, with treatment cycles varying depending on the condition being treated and the individual patient's response.
Key risks / contraindications
SS-31, like other peptide therapies, carries a risk of allergic reactions or anaphylaxis. It should not be used in patients with a known hypersensitivity to the peptide or any of its components. Additionally, its safety in pregnant or breastfeeding women is not well-established.
Bottom line
SS-31 is a mitochondria-targeted peptide with potential therapeutic benefits in conditions associated with mitochondrial dysfunction and oxidative stress. Its use is primarily investigational, and further research is needed to fully understand its mechanisms and establish its safety and efficacy profile.
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