Class & Mechanism
Tesamorelin is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH), specifically a 29-amino acid fragment of the natural 44-amino acid peptide. It acts as a potent stimulator of growth hormone (GH) release from the anterior pituitary gland by binding to the GRF receptor, thereby increasing circulating GH levels.
Research-documented benefits
– Stimulates IGF-1 and triggers the production of muscle protein [6].
– Decreases visceral fat and reduces levels of triglycerides in the blood [6].
General-knowledge benefits
– Used in clinical practice to treat adult growth hormone deficiency, improving body composition and reducing fat mass [5].
– May improve muscle strength and physical performance in GH-deficient patients [5].
Typical injectable protocol
Adult human doses typically range from 1 mg to 3 mg, administered subcutaneously once or twice daily for a twelve-week cycle, preferably preworkout or with the first meal of the day [6].
Key risks / contraindications
– May cause side effects related to GH excess, such as fluid retention, joint pain, and potential worsening of sleep apnea.
– Not recommended for individuals with a history of cancer or pituitary disorders due to the potential for exacerbating GH-related conditions.
Bottom line
Tesamorelin is a therapeutic peptide used to treat growth hormone deficiency and improve body composition in adults. It is not approved for off-label use such as anti-aging or athletic performance enhancement.
References
- Aging and genome maintenance_ lessons from the growth hormone receptor knockout mouse
- Anabolics
- Anabolics 10th Edition
- Basic and Clinical Aspects of Growth Hormone
- Biochemistry
- Boundless Upgrade Your Brain, Optimize Your Body and Defy — Ben Greenfield
- Endocrinology_ Adult and Pediatric
- Energy Metabolism and Obesity_ Research and Clinical Applications
- GHRH, GH, and IGF-1_ Basic and Clinical Advances
- Grow young with HGH _ the amazing medically proven plan to
- Growth Hormone Secretagogues
- Growth Hormone Secretagogues in Clinical Practice
- Growth hormone releasing peptides
- Handbook of Biologically Active Peptides
- Life Force
- Live Longer, Live Well_ The 6 Lifestyle Pillars for a Long and Healthy Life
- Living a Fully Optimized Life
- Mass Spectrometry in Medicinal Chemistry
- Peptides and Non Peptides of Oncologic and Endocrine Interest
- Performance-Enhancing Substances in Sport and Exercise
- Psoriasis_ Targets and Therapy
- Surgical versus medical therapy of prolactinomas
- The Encyclopaedia of Sports Medicine_ An IOC Medical Commission Publication
- The Metabolic and Molecular Bases of Inherited Disease
- The Synthesis of Polynucleotides