Class & Mechanism
Delta Sleep-Inducing Peptide (DSIP) is a 9-peptide first isolated from the cerebral venous blood of sleeping rabbits. It is widely distributed in the brain and other tissues, with concentrations increasing during hibernation. DSIP is thought to mediate sleep-like states, particularly delta-slow-wave sleep, after intraventricular application into the brain. However, the exact mechanisms and receptors involved are not well characterized [9][10].
Research-documented benefits
– Mediates sleep-like states (delta-slow-wave sleep) after intraventricular application into the rabbit brain [9].
– DSIP passes the blood-brain barrier [9].
General-knowledge benefits
– DSIP was initially regarded as a candidate sleep-promoting factor, but the link between DSIP and sleep has not been further characterized due to the lack of isolation of the DSIP gene, protein, and related receptor.
Typical injectable protocol
Research-only. The exact dosing protocol is not standardized and varies based on the study design and animal models used.
Key risks / contraindications
– DSIP's effects on sleep and wakefulness are not fully understood, and more research is needed to elucidate its mechanisms and potential therapeutic applications.
– It should be used with caution in individuals with sleep disorders or those taking medications that affect sleep patterns.
Bottom line
DSIP is a peptide with potential sleep-inducing effects, but its mechanisms and therapeutic applications are not well characterized and require further research.
References
- Basic and Clinical Aspects of Growth Hormone
- Boundless Upgrade Your Brain, Optimize Your Body and Defy — Ben Greenfield
- Growth Hormone Secretagogues
- Growth Hormone Secretagogues in Clinical Practice
- Handbook of Biologically Active Peptides
- Handbook of Neurochemistry and Molecular Neurobiology_ Neurotransmitter Systems
- Kosmetik für Ärzte und Apotheker
- Life Force
- Molecular Neuroscience
- Neuroprotective Effects of Tripeptides—Epigenetic Regulators — Khavinson, Vladimir (author)
- Peptide Protocols Volume One — William A Seeds MD
- Peptide drug discovery and development _ Translational — edited by Miguel Castanho and
- Peptides_ Chemistry and Biology, 2nd Edition
- Pharmacological Sciences_ Perspectives for Research and Therapy in the Late 1990s
- The Perricone Prescription
- The glucagon-like peptides